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Wang R-Q et al

doi: 10.1111/bph.14585 70 MedalaVKGollapelliBDewanjeeSOgunmokunGKandimallaRVallamkonduJ

Diabetes Care 2018;41:547-553

In comparison, a small molecule like orforglipron is a roughly 16-step convergent organic synthesis from common starting materials (see, e.g., Part I and Part II of a key intermediate synthesis from the Lilly process team)