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The mechanisms include vascular disease, hormonal imbalances (particularly reduced testosterone in men), psychological factors, and reduced physical stamina

The type of B12 supplement might matter too

emptying is influenced by concurrently ingested liquids [62] and may relate to weight loss [63]

While its too early to say if MOTS-c will extend human lifespan, the goal is that it could extend healthspan keeping people energetic and metabolically healthy as they age