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JAMA 273 , 5965 (1995)

The Zepbound (tirzepatide) label recommends switching to a non-oral birth control method, or adding a barrier method, for 4 weeks after starting Zepbound and for 4 weeks after each dose increase

But Heckmann says the emotional tone has shifted

The abdomen typically has the thickest subcutaneous fat layer of any approved injection site, with average depths of 12 to 20 millimeters depending on body composition