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To put this in simple terms, acetaldehyde effectively behaves like a short-term poison that your body urgently wants to neutralise

Nazrolu M (2007) New molecular mechanisms on the activation of TRPM2 channels by oxidative stress and ADP-ribose

Collectively, these studies indicate that these molecules constitute complex autocrine/paracrine networks to regulate cell proliferation, survival, and differentiation, controlling the pace of cartilage and bone development and remodeling